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BCL-XL (B-cell lymphoma-extra large), an anti-apoptotic member of the BCL-2 family proteins, is prominently found in the inner membrane of mitochondria and characterized by containing all four BCL-2 homology (BH) domains (BH1 to BH4). A hydrophobic cleft (the BH3-binding groove) formed by apposition of the BH1, BH2 and BH3 domains has been identified in the molecular surface of BCL-XL, through which it interacts with pro-apoptotic BCL-2 proteins, Bax and Bak, to inhibit apoptosis. Moreover, BCL-XL also exhibits anti-autophagy abilities to avoid autophagic cell death by binding to protein Beclin 1, which is required to initiate the formation of autophagasome in autophagy.

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  1. Cat.No. Product Name Information
  2. B6163 A-1155463 BCL-XL inhibitor, potent and selective
  3. B6164 A-1331852 BCL-XL inhibitor, potent and selective
  4. A8193 ABT-737 Bcl-2 inhibitor
  5. A3424 Gambogic Acid Caspase activator and apoptosis inducer
  6. A8168 HA14-1 Bcl-2 inhibitor,potent and cell-permeable
  7. A4234 TW-37 Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1
  8. A3935 WEHI-539 Bcl-xL inhibitor,potent and selective
  9. A8634 WEHI-539 hydrochloride Bcl-xL inhibitor,high affinity and selective

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